When you setup a box with vagrant and virtualbox and got this error message: Error while connecting to libvirt: Error making a connection to libvirt URI qemu:///system?no_verify=1&keyfile=/home/username/.ssh/id_rsa: Call to virConnectOpen failed: Failed to connect socket to '/var/run/libvirt/libvirt-sock': No such file or directory the reason you can't run the vagrant box is because your Virtualbox is not recognized by Vagrant Script. You can fix this by run vagrant use virtualbox as  the provider. [sourcecode]vagrant up --provider virtualbox[/sourcecode] if you lucky, the box will start and booting. but, if you got this error: The provider 'virtualbox' that was requested to back the machine 'default' is reporting that it isn't usable on this system. The reason is shown below: Vagrant has detected that you have a version of VirtualBox installed that is not supported by this version of Vagrant. Please install one of the supported versions listed below to use Vagrant: 4.0, 4.1, 4.2, 4.3, 5.0, 5.1, 5.2, 6.0 A Vagrant update may also be available that adds support for the version you specified. Please check www.vagrantup.com/downloads.html to download the latest version. so, you need to update your Vagrant script. [sourcecode]wget https://releases.hashicorp.com/vagrant/2.2.10/vagrant_2.2.10_x86_64.deb sudo dpkg -i vagrant_2.2.10_x86_64.deb[/sourcecode] and then start the box again [sourcecode]vagrant up[/sourcecode]